Immunotherapy for Endometrial Cancer

Immunotherapy uses the body’s natural defenses (the immune system) to find, attack, and kill cancer cells.

Immunotherapy can be used in combination with targeted therapies for people with advanced endometrial cancer that tests negative to MSI-high or dMMR, after other treatment has been tried. It can also be used with chemotherapies for MSI-high or dMMR recurrent endometrial cancers. 

These are the immunotherapy drugs that are used most often to treat endometrial cancer. New treatments become available all the time, so this may not be a complete list. 

Please note: The side effects listed here do not represent a comprehensive list. Each immunotherapy drug has its own set of side effects and ways of working. It's important to discuss all potential side effects of a drug with your healthcare team. Be sure to tell your healthcare team about any side effects you do have. 

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All Available Treatments

IV (through a vein) =      Pill =

Treatment Type

PD-1 Inhibitors 

Drug Names
Keytruda® (Pembrolizumab) (IV)
Imfinzi® (Durvalumab) (IV)
Jemperli® (Dostarlimab) (IV)
Opdivo® (Nivolumab) (IV)
Bavencio® (Avelumba) (IV)
Potential Side Effects
Fatigue/weakness Fever Cough Nausea/vomiting Skin/nail changes Weight/appetite changes Muscle pain Shortness of breath Constipation Diarrhea
Important Things to Know
  • These drugs may cause infusion or autoimmune reactions that could be potentially severe.

  • These drugs boost your immune system response against cancer cells. They do this by targeting PD-1, a protein on T cells. T cells are a part of your immune system.