Targeted Therapy for Melanoma

Targeted therapy uses drugs to target specific changes in cancer cells that help them grow, divide, and spread. Targeted therapy drugs are designed to be more precise. They fight cancer cells while causing less harm to other cells in the body.  

These are the latest targeted therapies that are approved to treat melanoma. New treatments become available all the time, so this may not be a complete list.

Please note: The side effects listed here do not represent a comprehensive list. It's important to discuss all potential side effects of a drug with your health care team. Be sure to tell your health care team about any side effects you do have.

Search by Drug Name

IV (through a vein) =      Pill =

Treatment Type

MEK Inhibitors

Drug Names
Cotellic® (cobimetinib) (Pill)
Mekinist® (trametinib) (Pill)
Mektovi® (binimteinib) (Pill)
Important Things to Know
  • These drugs are used for BRAF+ melanoma.
  • Low blood counts are a potential side effect that may put you at risk for anemia, infection, or bleeding.
  • Muscle damage is a rare but serious side effect.

Treatment Type

BRAF Inhibitors

Drug Names
Braftovi® (encorafenib) (Pill)
Tafinlar® (dabrafenib) (Pill)
Zelboraf® (vemurafenib) (Pill)
Important Things to Know
  • These drugs are used for BRAF+ melanoma.
  • If you experience any pain, be sure to report it to your health care team.

Treatment Type

C-KIT Inhibitors

Drug Names
Gleevec® (imatinib) (Pill)
Tasigna® (nilotinib) (Pill)
Important Things to Know
  • These drugs are used for C-KIT+ melanoma.
  • Low blood counts are a potential side effect that may put you at risk for anemia, infection, or bleeding.