Symptoms of Myelofibrosis

Myelofibrosis typically develops very slowly and, therefore, symptoms may not be commonly seen early in the disease process. However, as the abnormal cells increase, more and more disruption in the functioning of the normal blood cells occur. Check with your doctor if you are experiencing:

Fatigue, weakness, or shortness of breath. These symptoms are associated with a decrease in the red blood cells (anemia)
Pain or fullness below the ribs on the left side, as a result of an enlarged spleen (splenomegaly)
Enlarged liver (hepatomegaly)
Pale skin
Easy bruising or bleeding, due to a decrease in the platelet count (thrombocytopenia)
Flat, red, pinpoint spots under the skin caused by bleeding (petechiae)
Excessive night sweats
Fever
Frequent infections, due to a low white blood cell count (neutropenia)
Bone or joint pain
Weight loss
Itching (pruritus)