What are Myeloproliferative Neoplasms (MPNs)?

Myeloproliferative Neoplasms (MPNs) are types of blood cancers that overproduce blood cells in the bone marrow, due to genetic mutations that originate in the stem cells. This genetic mutation leads to the overproduction of white blood cells, red blood cells, and platelets in the bone marrow. 

MPNs were previously identified as “Myeloproliferative Disorder” or “Myeloproliferative Disease” (MPDs).  In 2008 the World Health Organization (WHO) reclassified MPDs to “Myeloproliferative Neoplasms” to reflect the consensus that these diseases are blood cancers (neoplasms).

There are 3 main types of MPNs:


Though myeloproliferative neoplasms are serious, and may pose certain health risks, people with these conditions often live for many years after diagnosis. The prognosis largely depends on the type of MPN.

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